The two teeth are going to make about a 5% difference (2/43 = 0.047) in your RPM. So cruising at 5000 rpm would become 5250. I would put it on and go unless your bike is near redline with the other gearing. I doubt you notice much difference.
A race car driving buddy told me anything less than a 10% change (I think ...) was hard to feel. Seems right to me.
Edit: Yes I have it backwards because my dislexia kicked in when I read the post ...

... dangit!
43 to a 45 will be a 5% reduction in rpm ... I still hold that this probably isn't enough to notice unless you are trying to climb something very steep in first gear near the stall point of the motor. Once you are out of first gear, and until you are in the last gear, this change won't make much of any difference, unless you shift by speed and not rpm. Each speed range for a set rpm range will increase by 5% ... adjust your shift points accordingly.
And BTW, Shiner is good beer!